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Book synopsis

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Book details

Book category Books in English Medicine Clinical & internal medicine Diseases & disorders

• Full title: Non-Myeloablative Allogeneic Transplantation
• Author: Edward D. Ball, Asad Bashey
• Language: English
• Binding: Paperback
• Number of pages: 216
• EAN: 9781461353041
• ISBN: 1461353041
• ID: 06796285
• Publisher: Springer-Verlag New York Inc.
• Weight: 361 g
• Dimensions: 235 × 155 × 13 mm
• Date of publishing: 30. October 2012

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