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Więcej informacji o Vesicular System Based Malaria Vaccine

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Opis

The Carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-119) was delivered directly into the cytoplasm via pH sensitive liposome. we have reported the preparation and characterization of PfMSP-119 encapsulated pH-sensitive liposomal formulations using oleyl alcohol (OAlc) in combination with egg phosphatidylcholine (EPC)and evaluated for intracellular cytosolic delivery of PfMSP-119 and as is evident from the results obtained; promising and significant immune responses were obtained by the cytosolic delivery of the malaria antigen through pH sensitive liposome. Moreover, after intramuscular immunization of PfMSP- 119 loaded pH sensitive liposomes, into Balb/c mice, the significant and perdurable IgG responses were obtained, as compared to conventional liposome loaded with PfMSP-119 and comparative evaluations have been marked with alum adsorbed malaria antigen. This may be attributed to good immuno-adjuvant action of pH sensitive liposomes, which are reported to enhance the immunogenicity of a soluble malaria antigen and present study might open new ways for the feasibility for the development of blood stage malaria vaccine.

Szczegóły książki

• Pełny tytuł: Vesicular System Based Malaria Vaccine
• Podtytuł: A Novel Approach
• Autor: Rajesh Singh Jadon, Anushree Tiwari, Suresh P Vyas
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 128
• EAN: 9783639292794
• ID: 06836370
• Wydawca: VDM Verlag Dr. Müller
• Waga: 207 g
• Wymiary: 220 × 150 × 8 mm
• Rok wydania: 2010

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