Zobacz książki o podobnej tematyce

Więcej informacji o Vascular Disruptive Agents for the Treatment of Cancer

• Dane szczegółowe
• Opis
• Ulubione w innej kategorii

Za ten zakup dostaniesz 446 punkty

Opis

Tumour survival and growth is critically dependent on an independent blood supply. As such tumour vasculature presents an ideal target for cancer therapy that is widely applicable, accessible and genetically stable rendering it less prone to resistance. Two approaches have been explored for cancer therapy; firstly the prevention of new vessel formation with inhibitors of angiogenesis, and secondly the destruction of existing tumour blood vessels with so called vascular disruptive agents (VDAs). While the first approach appears to delay tumour progression, the second has the potential to cause massive cell death and tumour regression. It si the second approach of vascular targeting that is the focus of this review. Since the tubulin binding agent combretastatin, derived from the bark of the African bush willow, was discovered by George R Pettit to have antimitotic properties over twenty years ago, the field of vascular targeting has expanded steadily. Coincident with the preclinical and clinical development of these agents, there have been advances in our understanding of their mechanism of action and in the technology required to assess their effects.

Szczegóły książki

Kategoria Książki po angielsku Medicine Clinical & internal medicine Diseases & disorders

• Pełny tytuł: Vascular Disruptive Agents for the Treatment of Cancer
• Autor: Tim Meyer
• Język: Angielski
• Oprawa: Twarda
• Liczba stron: 256
• EAN: 9781441966087
• ISBN: 1441966080
• ID: 01424021
• Wydawca: Springer-Verlag New York Inc.
• Waga: 620 g
• Wymiary: 235 × 155 × 21 mm
• Data wydania: 10. September 2010

Ulubione w innej kategorii

---

---

---