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Opis

Integrin-mediated adhesive interactions of cells with the extracellular matrix (ECM) regulate important cellular functions and play a critical role in disease. Therefore, studying the mechanisms underlying integrin-binding and regulation is of great interest. In the presented work three respective biological questions have been addressed using Atomic Force Microscopy based Single Cell Force Spectroscopy (AFM-SCFS). The work is split into six chapters. The first chapter provides an introduction into cell-ECM interactions. Thereafter different adhesion assays are compared and contrasted, and the theoretical Bell-Evans model is discussed. In chapter four, alpha2beta1-integrin mediated cell adhesion to collagen I is quantified. Thereafter the effects of the exposure of cryptic integrin binding sites within collagen I on pre-osteoblasts are analysed. At last, the role of BCR/ABL in modulating myeloid progenitor cell adhesion to stromal cells and ECM-coated substrates is studied. Taken together, the work demonstrates that AFM-SCFS is a versatile tool that permits monitoring of cell adhesion from single-molecule recognition events to the formation of more complex adhesion sites.

Szczegóły książki

Kategoria Książki po angielsku Mathematics & science Biology, life sciences

• Pełny tytuł: Quantifying Cell-Ecm Adhesion by Single Cell Force Spectroscopy
• Autor: Anna Taubenberger
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 184
• EAN: 9783838124278
• ISBN: 3838124278
• ID: 07116518
• Wydawca: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Waga: 277 g
• Wymiary: 229 × 152 × 12 mm
• Data wydania: 06. March 2011

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