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Opis

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve drug-like characteristics in addition to efficacy properties and good safety profiles of drug candidates.§Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.§

Szczegóły książki

Kategoria Książki po angielsku Medicine Other branches of medicine Pharmacology

• Pełny tytuł: Optimization in Drug Discovery
• Podtytuł: In Vitro Methods
• Autor: Gary W. Caldwell, Zhengyin Yan
• Język: Angielski
• Oprawa: Twarda
• Liczba stron: 597
• EAN: 9781627037419
• ISBN: 1627037411
• ID: 02067260
• Wydawca: Humana Press Inc.
• Waga: 1339 g
• Wymiary: 254 × 178 × 38 mm
• Data wydania: 09. November 2013

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