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Opis

NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-?B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.

Szczegóły książki

Kategoria Książki po angielsku Mathematics & science Biology, life sciences Biochemistry

• Pełny tytuł: Nf-Kb, a Network Hub Controlling Immunity, Inflammation, and Cancer
• Autor: Michael Karin
• Język: Angielski
• Oprawa: Twarda
• Liczba stron: 271
• EAN: 9780879699024
• ISBN: 0879699027
• ID: 04752741
• Wydawca: Cold Spring Harbor Laboratory Press,U.S.
• Waga: 768 g
• Wymiary: 267 × 187 × 20 mm
• Data wydania: 11. May 2010

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