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Opis

In this study, we present novel insights into mechanisms that account for the ER -dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ER -overexpression (ER -OE), we first demonstrated that this was associated with an increase of LVM at the basal level in both female and male mice. After MI, the cardiomyocyte-specific ER -OE inhibited changes in LV-volumes and wall thickness only in female mice. These beneficial effects in female ER -OE hearts were associated with increased angiogenesis and lymphangiogenesis, attenuated ventricular fibrosis and enhanced JNK phosphorylation. This study indicates that in the female sex, ER in cardiomyocytes may have a therapeutic potential in the treatment of ischemic heart disease, leading to more efficient cardiac repair after ischemic injury.

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Kategoria Książki po angielsku Medicine Medicine: general issues

• Pełny tytuł: Female sex and ER-alpha modulate cardiac ischaemic remodeling
• Autor: Zhang Xiang
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 92
• EAN: 9783838151281
• ISBN: 3838151283
• ID: 09501475
• Wydawca: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Waga: 145 g
• Wymiary: 229 × 152 × 7 mm
• Data wydania: 03. July 2015

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