Kod: 09501475
In this study, we present novel insights into mechanisms that account for the ER -dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a card ... więcej
Za ten zakup dostaniesz 167 punkty
In this study, we present novel insights into mechanisms that account for the ER -dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ER -overexpression (ER -OE), we first demonstrated that this was associated with an increase of LVM at the basal level in both female and male mice. After MI, the cardiomyocyte-specific ER -OE inhibited changes in LV-volumes and wall thickness only in female mice. These beneficial effects in female ER -OE hearts were associated with increased angiogenesis and lymphangiogenesis, attenuated ventricular fibrosis and enhanced JNK phosphorylation. This study indicates that in the female sex, ER in cardiomyocytes may have a therapeutic potential in the treatment of ischemic heart disease, leading to more efficient cardiac repair after ischemic injury.
Kategoria Książki po angielsku Medicine Medicine: general issues
66.76 €
Osobní odběr Bratislava a 2642 dalších
Copyright ©2008-24 najlacnejsie-knihy.sk Wszelkie prawa zastrzeżonePrywatnieCookies
Nákupní košík ( prázdný )