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Opis

The introduction of enzymes as catalysts into synthetic organic chemistry opened access to many new and highly enantioselective transformations. Baeyer-Villiger oxidation using biocatalysts represents a powerful methodology for the one-step asymmetric synthesis of chiral lactones. Due to a large number of different Baeyer-Villiger monooxygenases (BVMOs) with so far unknown biocatalytic properties the development of an efficient screening methodology based on microscaled whole-cell biotransformations became mandatory. The fermentation optimization of whole-cell mediated Baeyer-Villiger oxidation was the next logical step. A two-in-one in situ substrate feeding and product removal concept (SFPR) using an adsorbent resin and a recombinant E.coli strain was elaborated. Several critical parameters of the fermentation process were optimized. This work spans from biocatalyst assignment within screening protocols to up-scaling of the process to, ultimately, applying this biotransformation in the synthesis of natural compounds. This book is a very valuable contribution to the scientific community especially for people which are interested in the field of applied biocatalysis.

Szczegóły książki

Kategoria Książki po angielsku Mathematics & science Chemistry Organic chemistry

• Pełny tytuł: Enzymatic Baeyer-Villiger Oxidation for Natural Product Synthesis
• Autor: Florian Rudroff
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 200
• EAN: 9783639020939
• ISBN: 9783639020939
• ID: 08909031
• Wydawca: VDM Verlag Dr. Mueller E.K.
• Waga: 272 g
• Wymiary: 229 × 152 × 11 mm
• Data wydania: 16. May 2008

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