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Opis

Understanding the dynamics and mechanism of protein folding continues to be one of the central problems in molecular biology. Peptide folding experiments characterize the dynamics and molecular mechanisms of the early events of protein folding. However, generally the highly flexible nature of peptides makes their bioactive conformation assessment reasonably difficult as peptides fold at very fast rates experimentally, requiring probing on the nanosecond time resolution. The present work focuses on the exploration of the conformational space of biologically active neuropeptides with the aim of characterizing their conformational profile. Specifically, bombesin, neuromedin B (NMB) and neuromedin C (NMC), have been chosen for the current investigations. This study would help students and scientific community to understand the role of computational simulation techniques in the filed of conformational sampling and peptide folding.

Szczegóły książki

• Pełny tytuł: Conformational Profile of Bombesin and Its Mammalian Analogues
• Podtytuł: Bioactive Conformation of Bombesin, Neuromedin B and Neuromedin C using Computer Simulation Techniques
• Autor: Parul Sharma
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 176
• EAN: 9783659219825
• ID: 07089635
• Wydawca: LAP Lambert Academic Publishing
• Waga: 278 g
• Wymiary: 220 × 150 × 11 mm
• Rok wydania: 2012

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