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Więcej informacji o Analytical studies on a standardized extract of Withania somnifera L.

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Opis

Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant with significant pharmacological properties like adaptogenic, antioxidant, hypoglycemic and anti-stroke effects. Several of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates phytochemical and analytical studies on NMITLI118RT+ a candidate drug under the CSIR umbrella (derived from a new chemotype of W. somnifera). Here we report the development validation and applications of a simple, rapid and reliable isocratic HPLC method for quantification of Withanolide A in NMITLI118RT+ on a CN column utilizing gliclazide as an internal standard which could detect Withanolide A at about 3.8 min and gliclazide (internal standard) at about 4.8 min with a linearity range of 2-20 µg/mL. A second method here reports the development and validation of a simple isocratic method for simultaneous estimation of Withanolide A and Withanone (sesquiterpene lactone markers) established on a C-18; 3µ column which could detect Withanolide A and Withanone at retention times of about 20.7 min and 21.6 min respectively in the linearity range of 2-50 µg/mL for both.

Szczegóły książki

• Pełny tytuł: Analytical studies on a standardized extract of Withania somnifera L.
• Autor: Hafsa Ahmad, Anil Dwivedi, Sarvesh Paliwal
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 52
• EAN: 9783330343207
• ID: 16819248
• Wydawca: LAP Lambert Academic Publishing
• Waga: 96 g
• Wymiary: 220 × 150 × 3 mm
• Rok wydania: 2017

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