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More about Up-regulation of RhoB by Large Clostridial Cytotoxins

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Book synopsis

Clostridium difficile toxins A (TcdA) and B (TcdB) are mono-glucosyltransferases that inactivate RhoA, Rac1, and Cdc42. By these means, the toxins cause actin re-organisation (cytopathic effect) and apoptosis (cytotoxic effect). The cytotoxic effect has generally been attributed to the inactivation of RhoA. Treatment of cultured cells with Clostridium difficile toxin A (TcdA) also causes RhoB up-regulation. This study focuses on the up-regulation of RhoB and its functional consequences in toxin-treated cells. §RhoB is up-regulated after treatment of fibroblasts with RhoA/B/C (TcdB, C. limosum C3) or H/K/N-Ras (C. sordellii lethal toxin) inactivating toxins. The up-regulation is based on transcriptional activation. p38 MAP kinase is identified as enhancer of RhoB up-regulation. Finally, RhoB is found to regulate TcdB-induced apoptosis.

Book details

Book category Books in English Mathematics & science Biology, life sciences Biochemistry

• Full title: Up-regulation of RhoB by Large Clostridial Cytotoxins
• Author: Johannes Hülsenbeck
• Language: English
• Binding: Paperback
• Number of pages: 68
• EAN: 9783639001686
• ISBN: 3639001680
• ID: 06810349
• Publisher: VDM Verlag Dr. Mueller E.K.
• Weight: 104 g
• Dimensions: 229 × 152 × 4 mm
• Date of publishing: 15. April 2008

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