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Book synopsis

Identification of novel tumour-specific genes and pathways is a key strategy to gain additional prognostic markers and to identify molecular targets for chemical and/or immunological therapy. The combination of subtractive cDNA libraries and cDNA microarrays lead to the identification of the human calcium-activated chloride channel 2 (CLCA2), a member of the family of calcium-activated cytoplasmic trans-membrane chloride channel proteins. CLCA2 is highly expressed in lung squamous cell carcinoma. In the course of this PhD-Thesis a preferential overexpression of CLCA2 was shown in human squamous cell carcinomas (SCC) of different origins. CLCA2 was confirmed as a promising target in SCC tumourigenesis by in silico analysis of expression data, loss-of-function studies in SCC cell lines by siRNA-mediated knock-down, preliminary IHC analyses, inducible expression in tumour cells in combination with a detailed mutational analysis, 3D-In vitro carcinoma assays in multicellular tumour spheroids, expression profiling studies on Affymetrix GeneChips, and by utilising a text- and data-mining program for identification of several interaction-networks.

Book details

Book category Books in English Mathematics & science Biology, life sciences Life sciences: general issues

• Full title: Role of Clca2 in Tumourigenesis
• Author: Daniela Scheer
• Language: English
• Binding: Paperback
• Number of pages: 240
• EAN: 9783838112008
• ISBN: 3838112008
• ID: 07086039
• Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Weight: 358 g
• Dimensions: 229 × 152 × 14 mm
• Date of publishing: 25. June 2010

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