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Book synopsis

Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R deficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced A accumulation. In addition A plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced A accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer s disease is most likely a compensatory phenomenon.

Book details

Book category Books in English Mathematics & science Biology, life sciences Life sciences: general issues

• Full title: Role of neuronal IGF-1R signaling in Alzheimer's disease
• Author: Moritz M. Hettich
• Language: English
• Binding: Paperback
• Number of pages: 116
• EAN: 9783838128788
• ISBN: 3838128788
• ID: 06960474
• Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Weight: 181 g
• Dimensions: 229 × 152 × 7 mm
• Date of publishing: 12. September 2011

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