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More about Rol' dopolnitel'nyh promotorov v regulyacii gena dps v kletkah E. coli.

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Book synopsis

Belok nukleoida Dps obladaet unikal'nym sochetaniem ferroxidaznoj i kondensirujushhej genom aktivnostej. Jeto pozvolyaet emu igrat' kljuchevuju rol' v zashhite bakterij ot shirokogo spektra himicheskih i fizicheskih faktorov. Transkripciya gena dps osushhestvlyaetsya s promotora, raspoznavaemogo osnovnym i stress-zavisimym sigma-faktorami. Krome nego, v regulyatornoj oblasti gena obnaruzheny dopolnitel'nye promotory, prisutstvujushhie tol'ko v genomah Escherichiae i blizkorodstvennyh bakterij. Nesmotrya na nizkuju transkripcionnuju aktivnost', oni neobhodimy dlya maximal'noj jexpressii gena dps i sposobny vypolnyat' regulyatornuju funkciju, osobenno v stressovyh usloviyah. Okazalos', chto dopolnitel'nye promotory mogut byt' platformoj dlya vzaimodejstviya ne tol'ko s faktorami transkripcii, sredi kotoryh obnaruzheny regulyatory genov metabolicheskih putej, no i samim belkom Dps, kotoryj v zavisimosti ot uslovij, mozhet byt' kak aktivatorom, tak i repressorom sobstvennogo gena. Strukturnaya organizaciya promotornoj oblasti gena dps, sledovatel'no, jevoljucionno optimizirovana dlya adaptacii ego jexpressii k razlichnym usloviyam rosta, chto pozvolyaet sopryagat' metabolicheskih status kletki E.coli so strukturnym sostoyaniem genoma.

Book details

• Full title: Rol' dopolnitel'nyh promotorov v regulyacii gena dps v kletkah E. coli.
• Author: Ul'yana Shvyreva, Mariya Tutukina, Ol'ga Ozolin'
• Language: Russian
• Binding: Paperback
• Number of pages: 116
• EAN: 9783659942082
• ISBN: 3659942081
• ID: 14226643
• Publisher: LAP Lambert Academic Publishing
• Weight: 189 g
• Dimensions: 220 × 150 × 7 mm
• Date of publishing: 06. September 2016

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