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More about Retrovirus Restriction in Primates and the Discovery of TRIMCyp

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Book synopsis

Cells derived from numerous primate species are known to resist HIV-1 infection, a finding that had limited the development of non-human primate models of AIDS. In recent years, several studies suggested that many primate-derived cell lines possess dominant factors that block infection by various retroviruses. In the work described here, one of these factors was identified as a protein named TRIM-Cyp. In addition to its potent ability to interfere with HIV infection, TRIM-Cyp also represents an important mechanism in the formation of new genes - it is a hybrid between two unrelated genes, created by the activity of a retrotransposon. TRIM-Cyp, and other TRIM5 proteins in various primates, are important determinants of retrovirus tropism, and reveal a great deal about the evolutionary arms race between retroviruses and their hosts.

Book details

• Full title: Retrovirus Restriction in Primates and the Discovery of TRIMCyp
• Author: David Sayah
• Language: English
• Binding: Paperback
• Number of pages: 144
• EAN: 9783836471077
• ID: 07085702
• Publisher: VDM Verlag Dr. Müller
• Weight: 198 g
• Dimensions: 220 × 150 × 7 mm
• Published: 2010

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