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Book synopsis

This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

Book details

Book category Books in English Medicine Medicine: general issues Medical equipment & techniques

• Full title: Resistance of Cancer Cells to CTL-Mediated Immunotherapy
• Author: Benjamin Bonavida, Salem Chouaib
• Language: English
• Binding: Hardback
• Number of pages: 353
• EAN: 9783319178066
• ISBN: 3319178067
• ID: 09249948
• Publisher: Springer International Publishing AG
• Weight: 7541 g
• Dimensions: 235 × 155 × 244 mm
• Date of publishing: 21. June 2015

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