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Book synopsis

Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. . Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases . Provides a "drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential . Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development . Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area . Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Book details

Book category Books in English Medicine Clinical & internal medicine Neurology & clinical neurophysiology

• Full title: Molecular Targets in Protein Misfolding and Neurodegenerative Disease
• Author: Pierfausto Seneci
• Language: English
• Binding: Hardback
• Number of pages: 314
• EAN: 9780128001868
• ISBN: 0128001860
• ID: 04495903
• Publisher: Elsevier Books
• Weight: 612 g
• Dimensions: 239 × 152 × 18 mm
• Date of publishing: 09. October 2014

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