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More about Multinuclear Pyrazolate-Based Copper Complexes Inspired by the CuZ-Site of N2O-Reductases

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Book synopsis

Enzymes with multicopper active sites play important roles in many biological processes. Recently a novel multinuclear copper site was discovered in N2O-Reductase and its exact structure and mechanism has been much discussed since then. The so called CuZ center contains a unique tetranuclear Cu4S2-Cluster, which is coordinated by seven histidine residues. Until now no synthetic model complex could be isolated that emulates the Cu4S2 core of the active site. In this thesis a new strategy towards such model systems is introduced. To mimic the nitrogen-rich environment of the copper ions, pyrazolate-based ligand scaffolds with chelating N-donor side arms are employed. The resulting binuclear metal complexes were isolated and fully characterized. Additionally the reactivity of these binuclear building blocks towards various sulfur-containing coligands and sulfur-transfer reagents was investigated.

Book details

• Full title: Multinuclear Pyrazolate-Based Copper Complexes Inspired by the CuZ-Site of N2O-Reductases
• Author: Vera Konstanzer
• Language: English
• Binding: Paperback
• Number of pages: 206
• EAN: 9783869559780
• ISBN: 3869559780
• ID: 12738838
• Publisher: Cuvillier Verlag
• Weight: 274 g
• Dimensions: 210 × 148 × 11 mm
• Date of publishing: 22. December 2011

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