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Book synopsis

This book illustrates some of the various molecular §mechanisms underlying synaptic plasticity in a §subfield of the rat hippocampus called dentate §gyrus (DG). Long-term potentiation (LTP) is a well-§known model for studying strengthening of synaptic §plasticity. In this study, LTP was induced in the §DG by intrahippocampal infusion of brain-derived §neurotrophic factor (BDNF-LTP). Alternatively, LTP §was induced at medial perforant path-granule cell §synapses by high frequency stimulation (HFS-LTP).§The aim of the study was investigation of §transcriptional and translational changes of §activity-regulated cytoskeleton-associated protein §(Arc/Arg3.1) as well as changes in activation of the §translation factors eIF4E (eukaryotic initiation §factor 4E) and eEF2 (eukaryotic elongation factor-2) §during LTP.§We have demonstrated rapid activation of both §translation factors and upregulation of Arc protein §during BDNF-LTP. Additionally, an approach based on §intrahippocampal infusion of Arc antisense §oligodeoxynucleotides showed the importance of §sustained Arc translation for the maintenance of §both BDNF-LTP and HFS-LTP during a restricted time §window.

Book details

Book category Books in English Mathematics & science Biology, life sciences Biochemistry

• Full title: LTP mechanisms in the dentate gyrus in vivo
• Author: Tambudzai Kanhema
• Language: English
• Binding: Paperback
• Number of pages: 132
• EAN: 9783639150483
• ISBN: 3639150481
• ID: 06823586
• Publisher: VDM Verlag
• Weight: 204 g
• Dimensions: 229 × 152 × 8 mm
• Date of publishing: 07. July 2009

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