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Book synopsis

There are the two type of HIV mainly they are HIV-1 and HIV-2. HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. genetic variation and evolution in the pol gene was studied, with special interests in resistance-associated mutations in HIV-2 infected patients failing antiretroviral treatment. There is observation in some mutations known to cause resistance in HIV-1 such as M184V, Q151M and E219D; but most resistance mutations appeared to differ from what is known in HIV-1. The main conclusion from this work is that specific algorithms for HIV-2 resistance interpretation are needed, because the algorithms for HIV-1 cannot be used. They were studied the evolution of co-receptor usage, neutralization escape and env gene sequence. It is reported that a switch from CCR5 to CXCR4 using virus during disease progression. They did not see a clear pattern of neutralization escape as is seen in HIV-1. A pattern of changes in the number of potential N-linked glycosylation sites during disease progression has been observed. HIV-2 has fewer potential N-linked glycosylation sites in V3.

Book details

• Full title: HIV Genetics Evaluation And Viral Dynamics
• Subtitle: Exploring HIV
• Author: Dhairya Y. Joshi, Bhuvan P. Raval, Ashok L. Ganure
• Language: English
• Binding: Paperback
• Number of pages: 60
• EAN: 9783846555415
• ID: 06976378
• Publisher: LAP Lambert Academic Publishing
• Weight: 107 g
• Dimensions: 220 × 150 × 4 mm
• Published: 2011

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