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Book synopsis

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.

Book details

Book category Books in English Mathematics & science Biology, life sciences Cellular biology (cytology)

• Full title: G Protein Methods and Protocols
• Subtitle: Role of G Proteins in Psychiatric and Neurological Disorders
• Author: Ram K. Mishra, Glen B. Baker, Alan A. Boulton
• Language: English
• Binding: Paperback
• Number of pages: 433
• EAN: 9781489942906
• ISBN: 1489942904
• ID: 02717126
• Publisher: Humana Press Inc.
• Weight: 652 g
• Dimensions: 229 × 152 × 25 mm
• Date of publishing: 16. August 2013

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