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Book synopsis

The aim of this work was to develop a vaccination strategy against hepatitis C virus (HCV), which should induce the double benefit of an antibody production and a T cell immune response. The T cell response and the antibody production were examined in different mouse strains after immunization with a DNA-vaccine, which leads to expression of a protein, and compared with the T cell response after immunization with the protein. §§Immunization with DNA alone did not induce antibody production, but was responsible for a high production of IFN-? in all mouse strains. The immunization with protein showed the opposite pattern. In all mouse strains a high antibody production was observed, but no relevant T cell response could be detected. §§The future aim will be to obtain an ideal double benefit from a vaccine, and eventually to enhance the effect observed in this work by using other adjuvants and/or other antigens of the HCV. The aim of this work was to develop a vaccination strategy against hepatitis C virus (HCV), which should induce the double benefit of an antibody production and a T cell immune response. The T cell response and the antibody production were examined in different mouse strains after immunization with a DNA-vaccine, which leads to expression of a protein, and compared with the T cell response after immunization with the protein. Immunization with DNA alone did not induce antibody production, but was responsible for a high production of IFN-? in all mouse strains. The immunization with protein showed the opposite pattern. In all mouse strains a high antibody production was observed, but no relevant T cell response could be detected. The future aim will be to obtain an ideal double benefit from a vaccine, and eventually to enhance the effect observed in this work by using other adjuvants and/or other antigens of the HCV.

Book details

Book category Books in English Medicine Medicine: general issues Medical equipment & techniques

• Full title: DNA-Vaccination against Hepatitis C
• Author: Dario A. Papi
• Language: English
• Binding: Paperback
• Number of pages: 60
• EAN: 9783836481724
• ISBN: 3836481723
• ID: 07044818
• Publisher: VDM Verlag Dr. Mueller E.K.
• Weight: 95 g
• Dimensions: 229 × 152 × 3 mm
• Date of publishing: 19. March 2008

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