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Book synopsis

Discovering & Developing Molecules with Optimal Drug-Like Properties provides a contemporary view on the latest research in the area that will help readers benchmark current best practices, new research techniques and strategies, and understanding of informatics. Written with an underlying theme of early collaboration opportunities between pharmaceutical and discovery sciences, emphasis is made of practical considerations, with the opportunities examined from a number of different perspectives to maximize utility to the reader. Questions like What properties of a molecule are important from a drug-like standpoint? and What are some of the new techniques and approaches that can be used to characterize and understand molecular properties relevant to molecule druggability? will be addressed in an objective scientific manner. The text covers: - in silico predictive tools - contemporary approaches to physiochemical measurements - case studies in lead optimization for drug-like properties - assessing the risk and challenges related to key physicochemical properties - design of molecules tailored for specific drug delivery approaches - the importance of phase discovery and selection on drug molecule development - use of physicochemical properties for preclinical formulation selection and early clinical formulations - new approaches to link physiochemical properties to formulation selection

Book details

Book category Books in English Technology, engineering, agriculture Industrial chemistry & manufacturing technologies Industrial chemistry

• Full title: Discovering and Developing Molecules with Optimal Drug-Like Properties
• Author: Allen C Templeton, Stephen R. Byrn, Roy J Haskell, Thomas E. Prisinzano
• Language: English
• Binding: Hardback
• Number of pages: 511
• EAN: 9781493913985
• ISBN: 1493913980
• ID: 02734389
• Publisher: Springer-Verlag New York Inc.
• Weight: 9044 g
• Dimensions: 235 × 155 × 34 mm
• Date of publishing: 31. October 2014

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