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Book synopsis

This volume focuses on the recent advances in understanding T cells are key players in antitumor immune responses and T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

Book details

Book category Books in English Medicine Medicine: general issues Medical equipment & techniques

• Full title: Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
• Author: Emmanuel Donnadieu
• Language: English
• Binding: Hardback
• Number of pages: 199
• EAN: 9783319422213
• ISBN: 3319422219
• ID: 12580552
• Publisher: Springer International Publishing AG
• Weight: 553 g
• Dimensions: 235 × 155 × 17 mm
• Date of publishing: 31. August 2016

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