You might also like

More about Biochemistry and Genetics of Recq-Helicases

• Book details
• Synopsis
• Trending among others

You get 304 loyalty points

Book synopsis

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

Book details

Book category Books in English Mathematics & science Biology, life sciences Life sciences: general issues

• Full title: Biochemistry and Genetics of Recq-Helicases
• Author: David B. Lombard
• Language: English
• Binding: Paperback
• Number of pages: 92
• EAN: 9781461355373
• ISBN: 1461355370
• ID: 06796392
• Publisher: Springer-Verlag New York Inc.
• Weight: 184 g
• Dimensions: 235 × 155 × 7 mm
• Date of publishing: 30. October 2012

Trending among others

---

---

---