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Book synopsis

Initsiiruyushchim momentom aterogeneza yavlyaetsya nakoplenie lipidov v intime arteriy v rezul'tate vzaimodeystviya kletok s assotsiatami modifitsirovannykh LNP. V nastoyashchey rabote provedeno uglublyennoe izuchenie mekhanizmov aterogennoy modifikatsii lipoproteidov nizkoy plotnosti (LNP), tsirkuliruyushchikh v krovi patsientov; issledovany mekhanizmy i rol' assotsiatsii LNP v aterogeneze. Ustanovlena diagnosticheskaya i prognosticheskaya znachimost' LNP-soderzhashchikh tsirkuliruyushchikh immunnykh kompleksov (TsIK), opredelyaemykh po urovnyu kholesterina v nikh (Kh-TsIK), v otnoshenii progressirovaniya rannego ateroskleroza. Pokazano, chto po diagnosticheskoy i prognosticheskoy znachimosti Kh-TsIK znachitel'no prevoskhodit shiroko primenyaemye dlya diagnostiki ateroskleroticheskikh zabolevaniy pokazateli lipidnogo obmena. Vyyavleny amfifil'nye polimery (polaksamery), kotorye v zavisimosti ot ikh gidrofobnykh svoystv vliyayut na samoproizvol'nuyu assotsiatsiyu LNP. Pokazano, chto polaksamery s bol'shey gidrofobnost'yu ostanavlivayut protsess assotsiatsii LNP, no ne vyzyvayut dissotsiatsiyu obrazovavshikhsya kompleksov. Eti veshchestva mozhno rassmatrivat' kak perspektivnye agenty s tochki zreniya pryamoy antiateroskleroticheskoy terapii.

Book details

• Full title: Aterogennaya modifikaciya lipoproteidov
• Subtitle: Rol' v aterogeneze
• Author: Aleksandra Aleksandrovna Mel'nichenko, Aleksandr Nikolaevich Orekhov, Igor' Aleksandrovich Sobenin
• Language: Russian
• Binding: Paperback
• Number of pages: 252
• EAN: 9783659243127
• ID: 07008430
• Publisher: LAP Lambert Academic Publishing
• Weight: 392 g
• Dimensions: 220 × 150 × 15 mm
• Published: 2013

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