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Book synopsis

This book describes a novel cell biological basis §contributing to aberrant innate immunity and §inflammation in the cystic fibrosis (CF) respiratory §tract. The first aspect covered involves the basis §for previously described hyperacidification of §organelles in CF cells, and how this phenomenon can §be pharmacologically corrected. The second aspect §focuses on the excessive production of a molecule §named Sialyl-Lewis X (Slx) in CF cells. Slx acts as §a receptor for neutrophils which cause excessive §damage in the CF bronchial epithelia. The third §aspect involves the discovery of attenuated §polymeric IgA transcytosis in CF cells, which may §contribute to excessive colonization of P. §aeruginosa. Future directions addressing these §aspects of the cell biology of CF are outlined.

Book details

Book category Books in English Medicine Clinical & internal medicine Diseases & disorders

• Full title: Aberrant Cell Biology in Cystic Fibrosis Cells
• Subtitle: Cell Biological Basis for Aberrant Function in Infection and Inflammation in Cystic Fibrosis Respiratory Epithelial Cells
• Author: Joseph Fazio
• Language: English
• Binding: Paperback
• Number of pages: 132
• EAN: 9783639166460
• ISBN: 3639166469
• ID: 06825020
• Publisher: VDM Verlag
• Weight: 204 g
• Dimensions: 229 × 152 × 8 mm
• Date of publishing: 11. June 2009

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