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Book synopsis

Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:* How epidemiological cohort studies can better integrate physiological (mechanistic) measures;* How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;* How gene hunters can benefit from recruiting samples selected for known exposures;* How environmental pathogens can be used as tools for gene hunting;* How to deal with potential spurious (statistical) interactions, and* How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).

Book details

Book category Książki po angielsku Medicine Medicine: general issues Public health & preventive medicine

• Full title: Genetic Effects on Environmental Vulnerability to Disease
• Author: Novartis Rutter
• Language: English
• Binding: Hardback
• Number of pages: 232
• EAN: 9780470777800
• ID: 04380263
• Publisher: John Wiley & Sons Inc
• Weight: 500 g
• Dimensions: 233 × 162 × 16 mm
• Date of publishing: 06. June 2008

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