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Opis

This book provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Detailed examinations of specific disorders, their protein misfolding, and available treatments are presented. The book guides readers through in vitro and in vivo studies of fibrillization, liquid-liquid phase separation, and computational analysis for predicting protein aggregation. A special focus is given to the intriguing world of functional amyloids found in humans, bacteria, and yeast, showcasing their beneficial roles and contributions to physiological functions. The positive aspects of fibril formation are explored. Furthermore, the book discusses the implications of aggregation and amyloid fibril formation in the realm of biotechnological products and therapeutics. It considers both drawbacks and advantages, exploring how these phenomena impact the development and application of biotechnological products. Introduction to the folding of protein and associated conditions leading to aggregation and linked pathology.Discussion of structural biology and computational methodologies for analysis of protein (mis)folding and aggregation.Description of functional amyloids and their biotechnological application.

Szczegóły książki

Kategoria Knihy po anglicky Mathematics & science Biology, life sciences Biochemistry

• Pełny tytuł: The Hidden World of Protein Aggregation
• Język: Angielski
• Oprawa: Twarda
• Liczba stron: 300
• EAN: 9780443293405
• ISBN: 0443293406
• ID: 44681864
• Wymiary: 229 × 152 mm
• Data wydania: 01. August 2024

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